Journal Articles - Natural Science - 2020

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Browsing Journal Articles - Natural Science - 2020 by Author "Asshaima Paramita Devi"
  • Publication
    Dilatatone, a new chlorinated compound from Parmotrema dilatatum
    ( 2020)
    Hoang-Vinh-Truong Phan
    ;
    Asshaima Paramita Devi
    ;
    Hoang-Duy Le
    ;
    Thanh-Trung Nguyen
    ;
    Huu-Hung Nguyen
    ;
    Tran-Thai-Duong Le
    ;
    Tai Hoang Nguyen
    ;
    Jirapast Sichaem
    ;
    Thuc-Huy Duong
    Chemical investigation of the lichen Parmotrema dilatatum led to the isolation of a new chlorinated compound, named dilatatone (1), along with a known compound, sernanderin (2). Their chemical structures were determined by analysis of their 1D and 2D NMR spectra, HRESIMS, and ECD data. Both compounds showed weak a-glucosidase inhibitor activity.
  • Publication
    Synthesis, α-glucosidase inhibition, and molecular docking studies of novel N-substituted hydrazide derivatives of atranorin as antidiabetic agents
    ( 2020)
    Thuc-Huy Duong
    ;
    Asshaima Paramita Devi
    ;
    Nguyen-Minh-An Tran
    ;
    Hoang-Vinh-Truong Phan
    ;
    Ngoc-Vinh Huynh
    ;
    Jirapast Sichaem
    ;
    Hoai-Duc Tran
    ;
    Mahboob Alam
    ;
    Thi-Phuong Nguyen
    ;
    Huu-Hung Nguyen
    ;
    Warinthorn Chavasiri
    ;
    Tien-Cong Nguyen
    A series of novel N-substituted hydrazide derivatives were synthesized by reacting atranorin, a compound with a natural depside structure (1), with a range of hydrazines. The natural product and 12 new analogues (2–13) were investigated for inhibition of α-glucosidase. The N-substituted hydrazide derivatives showed more potent inhibition than the original. The experimental results were confirmed by docking analysis. This study suggests that these compounds are promising molecules for diabetes therapy. Molecular dynamics simulations were carried out with compound 2 demonstrating the best docking model using Gromac during simulation up to 20 ns to explore the stability of the complex ligand-protein. Furthermore, the activity of all synthetic compounds 2–13 against a normal cell line HEK293, used for assessing their cytotoxicity, was evaluated.