Journal Articles - Natural Science - 2020

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Browsing Journal Articles - Natural Science - 2020 by Author "Dinh-Tri Mai"
  • Publication
    Parmosidone K, A New Meta depsidone from The Lichen Parmotrema Tsavoense
    ( 2020)
    Thi-Hoai-Thu Nguyen
    ;
    Thi-My-Nhung Nguyen
    ;
    Thanh-Trung Nguyen
    ;
    Huu-Hung Nguyen
    ;
    Ngoc-Hong Nguyen
    ;
    Dinh-Tri Mai
    ;
    Bui-Linh-Chi Huynh
    ;
    Cong-Luan Tran
    ;
    Thuc-Huy Duong
    Further phytochemical investigation on P. tsavoense led to one new meta-depsidone, parmosidone K together with one known compound, barbatic acid. Their structures were determined by 1D and 2D NMR analysis, high resolution mass spectroscopy, and comparison their NMR data with those reported in literatures. Parmosidone K was evaluated for α-glucosidase inhibition and revealed the powerful activity with IC50 value of 3.12 µM.
  • Publication
    Subnudatones A and B, new trans-decalin polyketides from the cultured lichen mycobionts of Pseudopyrenula subnudata
    ( 2020)
    Thuc-Huy Duong
    ;
    Hung-Huy Nguyen
    ;
    Thanh-Trung Le
    ;
    Thanh-Nha Tran
    ;
    Jirapast Sichaem
    ;
    Thanh-Trung Nguyen
    ;
    Thi-Phuong Nguyen
    ;
    Dinh-Tri Mai
    ;
    Huu-Hung Nguyen
    ;
    Hoang-Duy Le
    Chemical investigation of the cultured polyspore-derived mycobionts of a Pseudopyrenula subnudata lichen led to the isolation of two new compounds, subnudatones A and B (1 and 2), together with four known compounds, 1- (2-hydroxy-1,2,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)ethanone (3), libertalide C (4), aspermytin A (5), and 6,7-dimethoxy-4-hydroxymellin (6). Their chemical structures were elucidated by extensive 1D and 2D NMR analysis and high resolution mass spectroscopy, and comparisons were made with the literature. The absolute configuration of 1 was defined unambiguously using single crystal X-ray crystallography. Compound 1 represents the first dimeric decalin polyketide to be found in nature. The in vitro cytotoxicity of 1 against two cancer cell lines (K562 and MCF-7) was evaluated. Compound 1 showed moderate cytotoxic activity with IC50 values of 23.5 ± 1.0 and 51.9 ± 1.4 μM, respectively.