Journal Articles - Natural Science - 2021

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Two new cycloartanes from the leaves of Combretum quadrangulare growing in Vietnam and their biological activities

( 2021)
Huu-Hung Nguyen
;
Thi-Phuong Nguyen
;
Nguyen Tien Trung
;
Cam-Tu D. Phan
;
Thi-Bich-Ngoc Dao
;
Dinh-Tri Mai
;
Jirapast Sichaem
;
Ngoc-Hong Nguyen
;
Cong-Luan Tran
;
Thuc-Huy Duong

Two novel cycloartanes, combretanones G and H (1 and 2), were isolated from the leaves of Combretum quadrangulare. Their structures were elucidated by applying a set of spectroscopic methods, while their relative configurations were determined using DFT-NMR chemical shift calculations and subsequent assignment of DP4 probabilities. Compounds 1 and 2 are C-23/C-24 stereoisomers of the previously-reported euphonerin E. Both exhibited moderate cytotoxicity against three human cancer cell lines. Compound 2 was shown to be a potent antiparasitic. Our results confirm the traditional medicinal uses of Combretum quadrangulare in Vietnam.