Journal Articles - Engineering Technology - 2022

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Browsing Journal Articles - Engineering Technology - 2022 by Subject "AgNPs"
  • Publication
    Fungi fabrication, characterization, and anticancer activity of silver nanoparticles using metals resistant Aspergillus niger
    ( 2022)
    Nguyen Thuy Lan Chi, Geetha Royapuram Veeraragavan, Kathirvel Brindhadevi, Arunachalam Chinnathambi, Saleh H. Salmen, Sulaiman Ali Alharbi, Ramakrishnan Krishnan, Arivalagan Pugazhendhi
    ings) metal-tolerant Aspergillus niger biomass filtrate and the anticancer potential of synthesized silver nanoparticles (AgNPs) tested with a Human Cervical cancer cell line (HeLa cells: Henrietta Lacks cells). The nitrate reduction test demonstrated that A. niger has the ability to reduce nitrate, and filtrate derived from A. niger biomass efficiently fabricated AgNPs from AgNO3, as demonstrated by a visible color change from pale greenish to brownish. The UV–visible spectroscopy analysis revealed an absorbance peak at 435 nm, which corresponded to the AgNPs. These AgNPs have been capped and stabilized with several functional groups related to various bioactive molecules such as aldehyde, benzene rings, aldehydic, amines, alcohols, and carbonyl stretch protein molecules. Fourier-Transform Infrared Spectroscopy (FTIR) analysis confirmed the capping and stabilizing chemical bonding pattern. Scanning Electron Microscopy (SEM) revealed that the synthesized AgNPs were spherical, with an average size of 21.38 nm. This bio-fabricated AgNPs has in-vitro anticancer potential when tested against the HeLa cell line due to its potential size and shape. At 100 g mL􀀀 1 concentrations of this biofabricated AgNPs, the anticancer activity percentage was found to be 70.2%, and the IC50 value was found to be 66.32 g m􀀀 1. These findings demonstrated that the metal-tolerant A. niger cell filtrate could produce AgNPs with anticancer potential.
  • Publication
    Phyto-fabrication of silver nanoparticle using leaf extracts of Aristolochia bracteolata Lam and their mosquito larvicidal potential
    ( 2022)
    Mathiyazhagan Narayanan, S. Priya, Devarajan Natarajan, Tahani Awad Alahmadi, Sulaiman Ali Alharbi, Ramakrishnan Krishnan, Nguyen Thuy Lan Chi, Arivalagan Pugazhendhi
    This research was designed to evaluate the fine quality of silver nanoparticles (AgNPs) fabricating proficiency of aqueous leaf extract of Aristolochia bracteolata and evaluate their larvicidal potential against I-IVth instar larvae and pupa of Culex quinquefasciatus. Within 24 h, the A. bracteolata aqueous leaf extract significantly reduced the AgNO3 and yielded AgNPs. It was initially confirmed by a visible color change from pale yellow to dark reddish brown in reaction mix and under UV–vis spectrum analysis the absorbance peak related to AgNPs was found at 430 nm. The nature of the phyto-synthesized AgNPs was characterized by standard analytical techniques such as Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Energy Dispersive X-Ray analyses (EDX). The A. bracteolata synthesized AgNPs were predominantly spherical in shape and size ranging from 29.30 to 46.32 nm. The percentage of Ag elemental composition was found as 57.61 % using EDX analysis. The A. bracteolata yielded AgNPs showed significant larvicidal and pupicidal efficiency on youngster (I-IVth instar larvae and pupa) of Culex quinquefasciatus mosquito vector. These results conclude that the aqueous leaf extract of A. bracteolata can produce biologically active AgNPs.