Biomedical products play an important role in maintaining human life, some parts are aesthetic role. The nasal prosthesis is used for aesthetic restoration for patients with damaged nose due to unwanted accidents. This paper presents the design and fabrication biomedical product used in transplant. Initially, the authors applied rapid prototyping technology Fused Deposition Modelling (FDM) in the fabrication of nasal prosthesis by material PLA (Poly Lactic - acid), silicon. Rapid-form, Solid-work software are used to build the shape of the nose, then use the 3D printers machine to make prototyping. Next, use the template to create plaster molds, final using plaster molds to cast nasal prosthesis by biomedical silicon.