This study tries to analyze how the Covid-19 epidemic has affected the profitability of Vietnam's real estate enterprises. The researchers collected data from sixty real estate enterprises in Vietnam from the final quarter of 2018 to the third quarter of 2021. This period encompasses the milestones that occurred before and during the Covid-19 pandemic. This study differentiates from previously published research by employing the statistical comparison approach and analyzing the profitability determinants of real estate enterprises across two time periods, before and during the Covid-19 pandemic, through regression.