Journal Articles - Life Science - 2021

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  • Publication
    Cynanchum Quangbinhense (Apocynaceae: Asclepiadoideae), A New Species from Vietnam, and Additional Information on C. officinale
    ( 2021)
    Phạm Văn Thế
    This research provides a description and illustrations for a new species from the Phong Nha-Ke Bang National Park, Cynanchum quangbinhense. The distribution, habitat, phenology and conservation assessment for the species are also presented. The new species differs from closely related species, C. ovalifolium in many characters such as leaf shape, inflorescence type, fewer and smaller flowers, colour of petals, margins of the corona, and anthers appendages shape, and differs from C. kwangsiense in having small leaves, umbellate inflorescences, triangular sepals, retuse apex of petals, and plicate margin of corona. Our discovery raises the known species of this genus in Vietnam to seven. In addition, a key to species of Cynanchum in Vietnam, and notes on morphological variation of C. officinale are presented in this paper.
  • Publication
    Simulated Microgravity Inhibits the Proliferation of Chang Liver Cells by Attenuation of the Major Cell Cycle Regulators and Cytoskeletal Proteins
    ( 2021)
    Chi Nguyen Quynh Ho
    ;
    Minh Thi Tran
    ;
    Chung Chinh Doan
    ;
    Son Nghia Hoang
    ;
    Diem Hong Tran
    ;
    Long Thanh Le
    Simulated microgravity (SMG) induced the changes in cell proliferation and cytoskeleton organization, which plays an important factor in various cellular processes. The inhibition in cell cycle progression has been considered to be one of the main causes of proliferation inhibition in cells under SMG, but their mechanisms are still not fully understood. This study aimed to evaluate the effects of SMG on the proliferative ability and cytoskeleton changes of Chang Liver Cells (CCL-13). CCL-13 cells were induced SMG by 3D clinostat for 72 h, while the control group were treated in normal gravity at the same time. The results showed that SMG reduced CCL-13 cell proliferation by an increase in the number of CCL-13 cells in G0/G1 phase. This cell cycle phase arrest of CCL-13 cells was due to a downregulation of cell cycle-related proteins, such as cyclin A1 and A2, cyclin D1, and cyclin-dependent kinase 6 (Cdk6). SMG-exposed CCL-13 cells also exhibited a downregulation of α-tubulin 3 and β-actin which induced the cytoskeleton reorganization. These results suggested that the inhibited proliferation of SMG-exposed CCL-13 cells could be associate with the attenuation of major cell cycle regulators and main cytoskeletal proteins.