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New diterpenoids from the stems of <i>Euphorbia antiquorum</i> growing in Vietnam
New diterpenoids from the stems of <i>Euphorbia antiquorum</i> growing in Vietnam
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Date
2020
Authors
Thanh-Nha Tran
Jirapast Sichaem
Van-Kieu Nguyen
Huu-Hung Nguyen
Truong-Tam Cao
Thi-Phuong Nguyen
Van-Giau Vo
Nakorn Niamnont
Ngoc-Hong Nguyen
Thuc-Huy Duong
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Abstract
Phytochemical analysis of Euphorbia antiquorum stem extracts afforded two
new ent-atisane compounds, ent-3α-acetoxy-16β,17,18-trihydroxyatisane (1)
and ent-3α,14,16β,17-tetrahydroxyatisane (2) together with three known
compounds, 20-deoxy-16-hydroxyingenol (3), ent-14[S],16α,17-
trihydroxyatisan-3-one (4), and agallochaol C (5). Their structures were
elucidated by spectroscopic data analysis and comparison with published NMR
data. Compounds 1-5 were evaluated for α-glucosidase inhibition and
cytotoxicity. Compounds 1, 4, and 5 revealed significant inhibitory activity
against α-glucosidase with the IC50 values of 119.9, 135.5, and 134.3 μM,
respectively. None showed activity in cytotoxicity assay.
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Keywords
"Euphorbiaceae,
Euphorbia antiquorum L.,
ent-atisane diterpenoid,
α-glucosidase inhibition"