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Two new cycloartanes from the leaves of Combretum quadrangulare growing in Vietnam and their biological activities
Two new cycloartanes from the leaves of Combretum quadrangulare growing in Vietnam and their biological activities
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Date
2021
Authors
Huu-Hung Nguyen
Thi-Phuong Nguyen
Nguyen Tien Trung
Cam-Tu D. Phan
Thi-Bich-Ngoc Dao
Dinh-Tri Mai
Jirapast Sichaem
Ngoc-Hong Nguyen
Cong-Luan Tran
Thuc-Huy Duong
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Abstract
Two novel cycloartanes, combretanones G and H (1 and 2), were isolated from the leaves of Combretum quadrangulare. Their structures were elucidated by applying a set of spectroscopic methods, while their relative configurations were determined using DFT-NMR chemical shift calculations and subsequent assignment of DP4 probabilities. Compounds 1 and 2 are C-23/C-24 stereoisomers of the previously-reported euphonerin E. Both exhibited moderate cytotoxicity against three human cancer cell lines. Compound 2 was shown to be a potent antiparasitic. Our results confirm the traditional medicinal uses of Combretum quadrangulare in Vietnam.
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Keywords
"Combretaceae,
Combretum quadrangulare,
Cycloartane,
Combretanones G and H"