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Electrochemical Determination of Uric Acid in Urine by Using Zeolite Imidazolate Framework-11 Modified Electrode
Electrochemical Determination of Uric Acid in Urine by Using Zeolite Imidazolate Framework-11 Modified Electrode
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Date
2021
Authors
Tran Si Thanh
Phan Tu Qui
Nguyen Thi Thanh Tu
Tran Thanh Tam Toan
Tran Thi Bich Hoa
Le Van Thanh Son
Do Mai Nguyen
Tran Ngoc Tuyen
Dinh Quang Khieu
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Abstract
In the present article, the synthesis of zeolite imidazole framework-11 (ZIF-11) by ultrasonic-assisted hydrothermal process and its
application as an electrode modifier for electrochemical determination of uric acid in urine are demonstrated. The obtained
materials were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), and nitrogen adsorption/desorption
isotherms. It was found that the ZIF-11 with rhombic dodecahedron topology and high surface area (1066m2.g-1) was synthesized
in a certain temperature and found in around 25–40°C, and other crystalline phases of zinc benzimidazolate deferring from ZIF-11
phase were found in less 25°C or higher than 40 ° C. The ZIF-11 is stable in the pH range 6-10. The modification of glassy carbon
electrode was performed with ZIF-67 using the drop-casting procedure. The present ZIF-11 modified electrode was employed to
study the electrochemical behavior of uric acid (UA). UA oxidation is catalyzed by this electrode in aqueous buffer solution (pH7)
with a decrease of 70mV in overpotential compared to glassy carbon electrode. With the differential pulse–anodic stripping
voltammetry (DP-ASV) method, the oxidation current of UA versus its concentration shows good linearity in the range 20–
540μM (R = 0:998) with a detection limit of 0.48 μM (S/N = 3). The obtained ZIF-11 modified electrode was applied in the
detection of UA content in urine samples, and satisfied results were obtained.