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Norquandrangularic acid D, a new trinorcycloartane isolated from the leaves of <i>Combretum quadrangulare</i>
Norquandrangularic acid D, a new trinorcycloartane isolated from the leaves of <i>Combretum quadrangulare</i>
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Date
2021
Authors
Huu-Hung Nguyen
Xuan-Hao Bui
Thi-Minh-Dinh Tran
Jirapast Sichaem
Thi-Kim-Dung Le
Ngoc-Hong Nguyen
Thuc-Huy Duong
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Abstract
Phytochemical investigation on the leaves of Combretum quadrangulare growing in Vietnam afforded a new trinorcycloartane triterpenoid, norquandrangularic acid D (1), along with three known compounds, betulinic acid (2), luteolin (3), and apigenin (4). Their structures were elucidated using spectroscopic methods and comparison was made with reports in the literature. Compounds 1 and 3 were evaluated for α-glucosidase inhibition. Compound 3 showed significant activity, with an IC50 value of 11.39 µM, (acarbose, used as a positive control, had an IC50 of 367 µM).