Publication:
Alpha-Glucosidase Inhibitory Diterpenes from Euphorbia antiquorum Growing in Vietnam
Alpha-Glucosidase Inhibitory Diterpenes from Euphorbia antiquorum Growing in Vietnam
| datacite.subject.fos | oecd::Natural sciences | |
| dc.contributor.author | Cong-Luan Tran | |
| dc.contributor.author | Thi-Bich-Ngoc Dao | |
| dc.contributor.author | Thanh-Nha Tran | |
| dc.contributor.author | Dinh-Tri Mai | |
| dc.contributor.author | Thi-Minh-Dinh Tran | |
| dc.contributor.author | Nguyen-Minh-An Tran | |
| dc.contributor.author | Van-Son Dang | |
| dc.contributor.author | Thi-Xuyen Vo | |
| dc.contributor.author | Thuc-Huy Duong | |
| dc.contributor.author | Jirapast Sichaem | |
| dc.date.accessioned | 2022-10-31T08:37:57Z | |
| dc.date.available | 2022-10-31T08:37:57Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Bioactive-guided phytochemical investigation of Euphorbia antiquorum L. growing in Vietnam led to the isolation of five ent-atisanes, one seco-ent-atisane, and one lathyrane (ingol-type). The structures were elucidated as ent-1α,3α,16β,17-tetrahydroxyatisane (1), ethyl ent-3,4-seco-4,16β,17-trihydroxyatisane-3-carboxylate (2), ent-atisane-3-oxo-16β,17-acetonide (3), ent-3α-acetoxy-16β,17-dihydroxyatisane (4), ent-16β,17-dihydroxyatisane-3-one (5), calliterpenone (6), and ingol 12-acetate (7). Their chemical structures were unambiguously determined by analysis of one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR) and high resolution mass spectrometry, as well as by comparison with literature data. Among them, 1 is a new compound while 2 is an ethylated artifact of ent-3,4-seco-4,16β,17-trihydroxyatisane-3-carboxylic acid, a new compound. Isolates were evaluated for alpha-glucosidase inhibition. Compound 3 showed the most significant inhibitory activity against alpha-glucosidase with an IC50 value of 69.62 µM. Further study on mechanism underlying yeast alpha-glucosidase inhibition indicated that 3 could retard the enzyme function by noncompetitive. | |
| dc.identifier.doi | 10.3390/molecules26082257 | |
| dc.identifier.uri | http://repository.vlu.edu.vn:443/handle/123456789/435 | |
| dc.language.iso | en_US | |
| dc.relation.ispartof | Molecules | |
| dc.relation.issn | 1420-3049 | |
| dc.subject | "Euphorbiaceae | |
| dc.subject | Euphorbia antiquorum L. | |
| dc.subject | ent-atisane | |
| dc.subject | diterpenoid | |
| dc.subject | alpha-glucosidase inhibition" | |
| dc.title | Alpha-Glucosidase Inhibitory Diterpenes from Euphorbia antiquorum Growing in Vietnam | |
| dc.type | journal-article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 8 | |
| oaire.citation.volume | 26 |