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New triterpene sulfates from Vietnamese red alga <i>Tricleocarpa fragilis</i> and their α-glucosidase inhibitory activity
New triterpene sulfates from Vietnamese red alga <i>Tricleocarpa fragilis</i> and their α-glucosidase inhibitory activity
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Date
2020
Authors
Thi Van Anh Tran
Van Minh Nguyen
Thi Ai Nhung Nguyen
Dat Huy Thanh Nguyen
Duy Hien Tran
Thi Phuong Thuy Bui
Van Tat Pham
The Han Nguyen
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Abstract
Three new compounds (methyl-3β,25-dihydroxycycloart-23-en-29-oate 3-sulfate (1), methyl-3β-hydroxy-25-methoxycycloart-23-en-29-oate 3-sulfate (2) and 3β-hydroxy-25-methoxycycloart-23-ene 3-sulfate (3)) and a known one (3β-hydroxycycloart-24-en-23-one 3-sulfate (4)) were isolated from Vietnamese red alga Tricleocarpa fragilis. All isolated compounds 1-4 showed potent inhibitory activity against yeast α-glucosidase with IC50 values of 16.62 ± 2.80, 36.34 ± 4.04, 30.19 ± 5.01 and 6.52 ± 0.17 µM, respectively. The docking data showed that the substitutions at C-3 and the differences in the side chain of cycloartane-skeleton could influence the interaction of molecule with enzyme, which was consistent with the experimental findings.
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Keywords
tricleocarpa fragilis,
cycloartane-type triterpene,
molecular docking simulation