Publication:
New triterpene sulfates from Vietnamese red alga <i>Tricleocarpa fragilis</i> and their α-glucosidase inhibitory activity
New triterpene sulfates from Vietnamese red alga <i>Tricleocarpa fragilis</i> and their α-glucosidase inhibitory activity
| datacite.subject.fos | oecd::Natural sciences | |
| dc.contributor.author | Thi Van Anh Tran | |
| dc.contributor.author | Van Minh Nguyen | |
| dc.contributor.author | Thi Ai Nhung Nguyen | |
| dc.contributor.author | Dat Huy Thanh Nguyen | |
| dc.contributor.author | Duy Hien Tran | |
| dc.contributor.author | Thi Phuong Thuy Bui | |
| dc.contributor.author | Van Tat Pham | |
| dc.contributor.author | The Han Nguyen | |
| dc.date.accessioned | 2022-11-09T11:28:43Z | |
| dc.date.available | 2022-11-09T11:28:43Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Three new compounds (methyl-3β,25-dihydroxycycloart-23-en-29-oate 3-sulfate (1), methyl-3β-hydroxy-25-methoxycycloart-23-en-29-oate 3-sulfate (2) and 3β-hydroxy-25-methoxycycloart-23-ene 3-sulfate (3)) and a known one (3β-hydroxycycloart-24-en-23-one 3-sulfate (4)) were isolated from Vietnamese red alga Tricleocarpa fragilis. All isolated compounds 1-4 showed potent inhibitory activity against yeast α-glucosidase with IC50 values of 16.62 ± 2.80, 36.34 ± 4.04, 30.19 ± 5.01 and 6.52 ± 0.17 µM, respectively. The docking data showed that the substitutions at C-3 and the differences in the side chain of cycloartane-skeleton could influence the interaction of molecule with enzyme, which was consistent with the experimental findings. | |
| dc.identifier.doi | 10.1080/10286020.2020.1783658 | |
| dc.identifier.uri | http://repository.vlu.edu.vn:443/handle/123456789/1148 | |
| dc.language.iso | en_US | |
| dc.relation.ispartof | Journal of Asian Natural Products Research | |
| dc.relation.issn | 1028-6020 | |
| dc.relation.issn | 1477-2213 | |
| dc.subject | tricleocarpa fragilis | |
| dc.subject | cycloartane-type triterpene | |
| dc.subject | molecular docking simulation | |
| dc.title | New triterpene sulfates from Vietnamese red alga <i>Tricleocarpa fragilis</i> and their α-glucosidase inhibitory activity | |
| dc.type | journal-article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 8 | |
| oaire.citation.volume | 23 |