Publication:
Subnudatones A and B, new trans-decalin polyketides from the cultured lichen mycobionts of Pseudopyrenula subnudata
Subnudatones A and B, new trans-decalin polyketides from the cultured lichen mycobionts of Pseudopyrenula subnudata
| datacite.subject.fos | oecd::Natural sciences | |
| dc.contributor.author | Thuc-Huy Duong | |
| dc.contributor.author | Hung-Huy Nguyen | |
| dc.contributor.author | Thanh-Trung Le | |
| dc.contributor.author | Thanh-Nha Tran | |
| dc.contributor.author | Jirapast Sichaem | |
| dc.contributor.author | Thanh-Trung Nguyen | |
| dc.contributor.author | Thi-Phuong Nguyen | |
| dc.contributor.author | Dinh-Tri Mai | |
| dc.contributor.author | Huu-Hung Nguyen | |
| dc.contributor.author | Hoang-Duy Le | |
| dc.date.accessioned | 2022-11-03T08:53:13Z | |
| dc.date.available | 2022-11-03T08:53:13Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Chemical investigation of the cultured polyspore-derived mycobionts of a Pseudopyrenula subnudata lichen led to the isolation of two new compounds, subnudatones A and B (1 and 2), together with four known compounds, 1- (2-hydroxy-1,2,6-trimethyl-1,2,4a,5,6,7,8,8a-octahydronaphthalen-1-yl)ethanone (3), libertalide C (4), aspermytin A (5), and 6,7-dimethoxy-4-hydroxymellin (6). Their chemical structures were elucidated by extensive 1D and 2D NMR analysis and high resolution mass spectroscopy, and comparisons were made with the literature. The absolute configuration of 1 was defined unambiguously using single crystal X-ray crystallography. Compound 1 represents the first dimeric decalin polyketide to be found in nature. The in vitro cytotoxicity of 1 against two cancer cell lines (K562 and MCF-7) was evaluated. Compound 1 showed moderate cytotoxic activity with IC50 values of 23.5 ± 1.0 and 51.9 ± 1.4 μM, respectively. | |
| dc.identifier.doi | 10.1016/j.fitote.2020.104512 | |
| dc.identifier.uri | http://repository.vlu.edu.vn:443/handle/123456789/838 | |
| dc.language.iso | en_US | |
| dc.relation.ispartof | Fitoterapia | |
| dc.relation.issn | 0367-326X | |
| dc.subject | "Pseudopyrenula subnudata | |
| dc.subject | Subnadatones A and B | |
| dc.subject | trans-decalin polyketide | |
| dc.subject | Cytotoxicity" | |
| dc.title | Subnudatones A and B, new trans-decalin polyketides from the cultured lichen mycobionts of Pseudopyrenula subnudata | |
| dc.type | journal-article | |
| dspace.entity.type | Publication | |
| oaire.citation.volume | 142 |
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