Publication:
Design, modification of phyllanthone derivatives as anti-diabetic and cytotoxic agents
Design, modification of phyllanthone derivatives as anti-diabetic and cytotoxic agents
| datacite.subject.fos | oecd::Natural sciences | |
| dc.contributor.author | Ngoc-Hong Nguyen | |
| dc.contributor.author | Van-Giau Vo | |
| dc.contributor.author | Hoang-Vinh-Truong Phan | |
| dc.contributor.author | Thanh-The Ngo | |
| dc.contributor.author | Jirapast Sichaem | |
| dc.contributor.author | Thi-Phuong Nguyen | |
| dc.contributor.author | Huu-Hung Nguyen | |
| dc.contributor.author | Duc-Dung Pham | |
| dc.contributor.author | Tien-Cong Nguyen | |
| dc.contributor.author | Van-Kieu Nguyen | |
| dc.contributor.author | Thuc-Huy Duong | |
| dc.date.accessioned | 2022-11-03T09:00:28Z | |
| dc.date.available | 2022-11-03T09:00:28Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Twelve benzylidene derivatives, one Baeyer-Villiger oxidative, six imine derivatives were successfully designed and synthesized from phyllanthone. In the search for potential new anti-diabetic agents, phyllanthone along with its benzylidene and oxidation analogues were evaluated for enzyme inhibition against α-glucosidase. In the benzylidene series, most analogues displayed stronger activity than the mother compound. 1c revealed the strongest activity, outperforming the acarbose positive control with an IC50 value of 19.59 μM. Phyllanthone and its derivatives were then tested for cytotoxic activity against the K562 cell line. The imine analogues displayed the most powerful cytotoxic activity with 3c, 3d having IC50 values of 57.55 and 68.02 μM, respectively. | |
| dc.identifier.doi | 10.1080/14786419.2020.1788023 | |
| dc.identifier.uri | http://repository.vlu.edu.vn:443/handle/123456789/846 | |
| dc.language.iso | en_US | |
| dc.relation.ispartof | Natural Product Research | |
| dc.relation.issn | 1478-6419 | |
| dc.relation.issn | 1478-6427 | |
| dc.subject | Phyllanthus (Phyllanthaceae) | |
| dc.subject | phyllanthone derivatives | |
| dc.subject | α-glucosidase inhibition | |
| dc.subject | cytotoxic activity | |
| dc.title | Design, modification of phyllanthone derivatives as anti-diabetic and cytotoxic agents | |
| dc.type | journal-article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 1 | |
| oaire.citation.volume | 36 |