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Design and synthesis of new lupeol derivatives and their <i>α</i>-glucosidase inhibitory and cytotoxic activities
Design and synthesis of new lupeol derivatives and their <i>α</i>-glucosidase inhibitory and cytotoxic activities
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Date
2020
Authors
Hoang-Vinh-Truong Phan
Thuc-Huy Duong
Duc-Dung Pham
Hoang-Anh Pham
Van-Kieu Nguyen
Thi-Phuong Nguyen
Huu-Hung Nguyen
Ngoc-Hong Nguyen
Pornpat Sam-ang
Kiettipum Phontree
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Abstract
were designed, synthesised and evaluated for their a-glucosidase
inhibitory and cytotoxic activities. Among synthetic derivatives,
lupeol analogues 2b and 2e containing a benzylidene chain
exhibited the best activity against a-glucosidase and superior to
the positive agent with the IC50 values of 29.4 ± 1.33 and
20.1 ± 0.91 lM, respectively. Lupeol analogues 2d and 3a showed
weak cytotoxicity against K562 cell line with the IC50 values of
76.6 ± 2.40 and 94.4 ± 1.51 lM, respectively.
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