Publication:
Design and synthesis of new lupeol derivatives and their <i>α</i>-glucosidase inhibitory and cytotoxic activities
Design and synthesis of new lupeol derivatives and their <i>α</i>-glucosidase inhibitory and cytotoxic activities
| datacite.subject.fos | oecd::Natural sciences | |
| dc.contributor.author | Hoang-Vinh-Truong Phan | |
| dc.contributor.author | Thuc-Huy Duong | |
| dc.contributor.author | Duc-Dung Pham | |
| dc.contributor.author | Hoang-Anh Pham | |
| dc.contributor.author | Van-Kieu Nguyen | |
| dc.contributor.author | Thi-Phuong Nguyen | |
| dc.contributor.author | Huu-Hung Nguyen | |
| dc.contributor.author | Ngoc-Hong Nguyen | |
| dc.contributor.author | Pornpat Sam-ang | |
| dc.contributor.author | Kiettipum Phontree | |
| dc.contributor.author | Jirapast Sichaem | |
| dc.date.accessioned | 2022-11-03T08:41:34Z | |
| dc.date.available | 2022-11-03T08:41:34Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | were designed, synthesised and evaluated for their a-glucosidase inhibitory and cytotoxic activities. Among synthetic derivatives, lupeol analogues 2b and 2e containing a benzylidene chain exhibited the best activity against a-glucosidase and superior to the positive agent with the IC50 values of 29.4 ± 1.33 and 20.1 ± 0.91 lM, respectively. Lupeol analogues 2d and 3a showed weak cytotoxicity against K562 cell line with the IC50 values of 76.6 ± 2.40 and 94.4 ± 1.51 lM, respectively. | |
| dc.identifier.doi | 10.1080/14786419.2020.1758095 | |
| dc.identifier.uri | http://repository.vlu.edu.vn:443/handle/123456789/828 | |
| dc.language.iso | en_US | |
| dc.relation.ispartof | Natural Product Research | |
| dc.relation.issn | 1478-6419 | |
| dc.relation.issn | 1478-6427 | |
| dc.subject | Retrieving data. Wait a few seconds and try to cut or copy again. | |
| dc.title | Design and synthesis of new lupeol derivatives and their <i>α</i>-glucosidase inhibitory and cytotoxic activities | |
| dc.type | journal-article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 1 | |
| oaire.citation.volume | 36 |