Publication:
Evaluation of the Anti Inflammatory and Anticancer Activities of Catechins Extracted from Green Tea (Camellia Sinensis) in Some Cancer Cell Lines

dc.contributor.author Ho Thi Ngoc Tram
dc.date.accessioned 2022-10-13T03:04:45Z
dc.date.available 2022-10-13T03:04:45Z
dc.date.issued 2020
dc.description.abstract Catechins from Green tea (Camellia sinensis) is widely known for many biological activities, special anti-cancer and anti-inflammatory properties. Catechins were extracted by mechanical blending, and using citric acid, with 2.31% in extraction efficiency. The result of determining by HPLC-UV showed that Catechin< EC < EGC < ECG < EGCG in concentration compared to dry powder, reaching a total content of 634.51 mg/g, higher than tea powder (537.65 mg/g). Then, anti-inflammatory and anticancer activities of these extracts were investigated. Cell viability assay (MTT) showed that catechin extracts were not toxic to Normal Human Dermal Fibroblasts Cells. They even exhibited anti-inflammatory activities by suppressing the production of NO and proinflammatory cytokines. The results also showed that the extracted catechin powder also showed good anti-inflammatory activity, at a concentration of 45 ?g/mL, NO proliferation reached 44.4%. Anticancer activities of these extracts were displayed through their ability to inhibit the growth of cancer cell lines: liver cancer cell line (HepG2), lung cancer cell line (A549), leukemia cancer cell line (K562), with IC50 values of 181.1 μg/mL, 186 μg/mL, 137.8 μg/mL, respectively. So catechin extracts from green tea may have the potential to be applied in pharmaceutical.
dc.identifier.uri http://repository.vlu.edu.vn:443/handle/123456789/250
dc.language.iso en_US
dc.relation.ispartof Southeast Asian Journal of Sciences
dc.relation.issn 2286-7724
dc.subject Green tea extract
dc.subject Camellia sinensis
dc.subject catechins
dc.subject anti-inflammatory
dc.subject anticancer
dc.subject HepG2
dc.subject A549
dc.subject K562
dc.title Evaluation of the Anti Inflammatory and Anticancer Activities of Catechins Extracted from Green Tea (Camellia Sinensis) in Some Cancer Cell Lines
dc.type Resource Types::text::journal::journal article
dspace.entity.type Publication
oaire.citation.endPage 149
oaire.citation.issue 2
oaire.citation.startPage 140
oaire.citation.volume 8
oairecerif.author.affiliation Van Lang University
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