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Nickel ferrite: synthesis and application for voltammetric determination of uric acid
Nickel ferrite: synthesis and application for voltammetric determination of uric acid
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Date
2021
Authors
Nguyen Thi Vuong Hoan
Nguyen Ngoc Minh
Nguyen Thi Lieu
Nguyen Van Thang
Vo Thang Nguyen
Nguyen Thi Thanh Tu
Tran Thanh Tam Toan
Nguyen Hoang Tuan
Duong Quang Nhan
Ho Van Minh Hai
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Abstract
In this paper, the synthesis of nickel ferrite
and its use for voltammetric determination of uric acid
(UA) are presented. Nickel ferrite was synthesized via a
hydrothermal process using spherical carbons as hard
template followed by calcination at 500 °C. It was found
that iron and nickel compositions in nickel ferrite can be
controlled by the initial Fe/Ni molar ratio. The stoichiometric
nickel ferrite (NiFe2O4) with hollow spherical
morphology was obtained from a reaction mixture with
Fe/Ni molar ratio of around 1.2–1.5. Glassy carbon
electrode modified with nickel ferrite was employed to
quantitatively determine UA by different pulse
voltammetric method. Under the optimum conditions,
the anodic peak current was linearly proportional to UA
concentration in the range of 0.398 to 6.761 μM. The
detection limit (3σ) was found to be 0.15 μM. The
proposed method has been employed to determine UA
in human urine samples with acceptable recoveries of
95.15–104.8%. On the other hand, the results obtained
from this method were also compared with that from
standard HPLC method, showing no statistical
difference.
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Keywords
"Uric acid,
Nickel ferrite,
Voltammetric determination,
Nanomaterials"