Publication:
Investigation into SARS-CoV-2 Resistance of Compounds in Garlic Essential Oil
Investigation into SARS-CoV-2 Resistance of Compounds in Garlic Essential Oil
| datacite.subject.fos | oecd::Natural sciences | |
| dc.contributor.author | Bui Thi Phuong Thuy | |
| dc.contributor.author | Tran Thi Ai My | |
| dc.contributor.author | Nguyen Thi Thanh Hai | |
| dc.contributor.author | Le Trung Hieu | |
| dc.contributor.author | Tran Thai Hoa | |
| dc.contributor.author | Huynh Thi Phuong Loan | |
| dc.contributor.author | Nguyen Thanh Triet | |
| dc.contributor.author | Tran Thi Van Anh | |
| dc.contributor.author | Phan Tu Quy | |
| dc.contributor.author | Pham Van Tat | |
| dc.contributor.author | Nguyen Van Hue | |
| dc.contributor.author | Duong Tuan Quang | |
| dc.contributor.author | Nguyen Tien Trung | |
| dc.contributor.author | Vo Thanh Tung | |
| dc.contributor.author | Lam K. Huynh | |
| dc.contributor.author | Nguyen Thi Ai Nhung | |
| dc.date.accessioned | 2022-11-02T03:05:04Z | |
| dc.date.available | 2022-11-02T03:05:04Z | |
| dc.date.issued | 2020 | |
| dc.description.abstract | Eighteen active substances, including 17 organosulfur compounds found in garlic essential oil (T), were identified by GC−MS analysis. For the first time, using the molecular docking technique, we report the inhibitory effect of the considered compounds on the host receptor angiotensin-converting enzyme 2 (ACE2) protein in the human body that leads to a crucial foundation about coronavirus resistance of individual compounds on the main protease (PDB6LU7) protein of SARS-CoV-2. The results show that the 17 organosulfur compounds, accounting for 99.4% contents of the garlic essential oil, have strong interactions with the amino acids of the ACE2 protein and the main protease PDB6LU7 of SARS-CoV- 2. The strongest anticoronavirus activity is expressed in allyl disulfide and allyl trisulfide, which account for the highest content in the garlic essential oil (51.3%). Interestingly, docking results indicate the synergistic interactions of the 17 substances, which exhibit good inhibition of the ACE2 and PDB6LU7 proteins. The results suggest that the garlic essential oil is a valuable natural antivirus source, which contributes to preventing the invasion of coronavirus into the human body | |
| dc.identifier.doi | 10.1021/acsomega.0c00772 | |
| dc.identifier.uri | http://repository.vlu.edu.vn:443/handle/123456789/649 | |
| dc.language.iso | en_US | |
| dc.relation.ispartof | ACS Omega | |
| dc.relation.issn | 2470-1343 | |
| dc.relation.issn | 2470-1343 | |
| dc.title | Investigation into SARS-CoV-2 Resistance of Compounds in Garlic Essential Oil | |
| dc.type | journal-article | |
| dspace.entity.type | Publication | |
| oaire.citation.issue | 14 | |
| oaire.citation.volume | 5 |