Open Access Books - Health Science - 2020

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Now showing 1 - 5 of 33
  • Publication
    The Summa Halensis: Doctrines and Debates
    ( 2020)
    Schumacher, Lydia::0000-0001-5092-6512::500
    The Summa Halensis (1236-45) was collaboratively authored by the founding members of the Franciscan school at Paris and represents not only the first official statement of Franciscan thought but also a defining text for the field of systematic theology. This volume brings together leading scholars who explore the diverse doctrines and debates, with a view to highlighting its innovativeness and influence on subsequent generations.
  • Publication
    Healthy Minds in the Twentieth Century: In and Beyond the Asylum
    ( 2020)
    Taylor, Steven J.;Brumby, Alice
    This open access edited collection contributes a new dimension to the study of mental health and psychiatry in the twentieth century. It takes the present literature beyond the ‘asylum and after’ paradigm to explore the multitude of spaces that have been permeated by concerns about mental well-being and illness. The chapters in this volume consciously attempt to break down institutional walls and consider mental health through the lenses of institutions, policy, nomenclature, art, lived experience, and popular culture. The book adopts an international scope covering the historical experiences of Britain, Ireland, and North America. In accordance with this broad approach, contributions to the volume span academic fields such as history, arts, literary studies, sociology, and psychology, mirroring the diversity of the subject matter. This book is available open access under a CC BY 4.0 license at link.springer.com
  • Publication
    New insights into creatine transporter deficiency: Identification of neuropathological and metabolic targets for treatment
    ( 2020)
    molinaro, angela::0000-0003-1690-5448::600
    Creatine (Cr) transporter deficiency (CCDS1) is a very rare and severe condition due to impaired energetic metabolism. In this work we showed for the first time the following facts: this diseases is a progressive neurodegenerative disorder in which a set of maladaptive compensatory mechanisms leads to a progressive damage of brain functions; cell energy metabolism and mitochondria seem strongly involved in the pathogenesis and they could represent useful potential targets for therapeutic interventions; inflammation seems to play an important part in this progressive damage, and this observation can pave the way to treatment strategies; neural circuits disruption involving inhibitory systems could give a huge contribute to many of the clinical aspects observed in patients, as epilepsy and cognitive impairment, since the excitatory/inhibitory balance is fundamental for the normal function of neural circuits. Factors outside the CNS are important in the pathogenesis of at least some aspects of the disorder, since the conditional KO model show difference in the timing of onset of some cognitive defects and in the presence of stereotypies.
  • Publication
    Medical Humanity and Inhumanity in the German-Speaking World:
    ( 2020)
    Puw Davies, Mererid;Shamdasani, Sonu::0000-0002-8729-8385::600
    Medical Humanity and Inhumanity in the German-Speaking World is the first volume dedicated to exploring the interface of medicine, the human and the humane in the German-speaking lands. The volume tracks the designation and making through medicine of the human and inhuman, and the humane and inhumane, from the Middle Ages to the present day. Eight individual chapters undertake explorations into ways in which theories and practices of medicine in the German-speaking world have come to define the human, and highlight how such theories and practices have consolidated, or undermined, notions of humane behaviour. Cultural analysis is central to this investigation, foregrounding the reflection, refraction and indeed creation of these theories and practices in literature, life-writing and other discourses and media. Contributors bring to bear perspectives from literary studies, film studies, critical theory, cultural studies, history, and the history of medicine and psychiatry. Thus, this collection is historical in the most expansive sense, for it debates not only what historical accounts bring to our understanding of this topic. It encompasses too investigation of life-writing, documentary, and theory and literary works to bring to light elusive, paradoxical, underexplored – yet vital – issues in history and culture.
  • Publication
    Good Research Practice in Non-Clinical Pharmacology and Biomedicine:
    ( 2020)
    Bespalov, Anton;Michel, Martin C.;Steckler, Thomas
    This open access book, published under a CC BY 4.0 license in the Pubmed indexed book series Handbook of Experimental Pharmacology, provides up-to-date information on best practice to improve experimental design and quality of research in non-clinical pharmacology and biomedicine.