Journal Articles - Natural Science - 2019

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Browsing Journal Articles - Natural Science - 2019 by Author "Nakorn Niamnont"

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    New diterpenoids from the stems of Euphorbia antiquorum growing in Vietnam
    (2020)
    Thanh-Nha Tran
    ;
    Jirapast Sichaem
    ;
    Van-Kieu Nguyen
    ;
    Huu-Hung Nguyen
    ;
    Truong-Tam Cao
    ;
    Thi-Phuong Nguyen
    ;
    Van-Giau Vo
    ;
    Nakorn Niamnont
    ;
    Ngoc-Hong Nguyen
    ;
    Thuc-Huy Duong
    Phytochemical analysis of Euphorbia antiquorum stem extracts afforded two new ent-atisane compounds, ent-3α-acetoxy-16β,17,18-trihydroxyatisane (1) and ent-3α,14,16β,17-tetrahydroxyatisane (2) together with three known compounds, 20-deoxy-16-hydroxyingenol (3), ent-14[S],16α,17- trihydroxyatisan-3-one (4), and agallochaol C (5). Their structures were elucidated by spectroscopic data analysis and comparison with published NMR data. Compounds 1-5 were evaluated for α-glucosidase inhibition and cytotoxicity. Compounds 1, 4, and 5 revealed significant inhibitory activity against α-glucosidase with the IC50 values of 119.9, 135.5, and 134.3 μM, respectively. None showed activity in cytotoxicity assay.