Study on the Ability of extracts from Cordyceps Spp. Biomass to prevent long term memory impairment in mice by morris water maze

The ability of three mycelial extracts of Cordyceps spp. (Poly DL0004, n-BuOH DL0015 and n-BuOH DL0006) to prevent long-time memory impairment of mice were tested by using Morris water maze model. Mice were induced memory impairment by Trymethyltin (TMT) as dose of 2.4 mg/kg (i.p. injection); then fed by solution of Cordyceps's mycelial extract as doses of 100 mg/kg (p.o) and 200 mg/kg (p.o); and test in Morris water maze model. The behavioral test of those mice was illustrated by concentration of neurotransmitter Acetylcholine (ACh) and its degraded enzyme Acetylcholinesterase (AChE) in their hippocampus. As results, Poly DL0004 and n-BuOH DL0015 had best effects on memory improvement at doses of 100 mg/kg in hidden platform test and probe test but no effect on working memory test. The concentrations of ACh and AChE in mice hippocampus were significant different between mice fed by Cordyceps's mycelial extract and negative control mice injected TMT dose of 2.4 mg/kg. No difference of concentrations of ACh and AChE were recorded between mice fed by extracts dose of 100 mg/kg and 200 mg/kg. The memory improvement effects of Cordyceps's mycelial extract were the first step to potentially apply Cordyceps products for human healthcare in Vietnam.