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Publication

Green synthesis of cobalt-oxide nanoparticle using jumbo Muscadine (Vitis rotundifolia): Characterization and photo-catalytic activity of acid Blue-74

( 2020)

Melvin S. Samuel

;

E. Selvarajan

;

Thangavel Mathimani

;

Needhidasan Santhanam

;

Tran Nhat Phuong

;

Kathirvel Brindhadevi

;

Arivalagan Pugazhendhi

In the recent years, plant and microbial extract based nanoparticles (NPs) have become a sophisticated technology serving as an alternative strategy for the purpose of developing materials functionalized by structural diversity and enhanced energy efficiencies. Cobalt oxide nanoparticles (GCoO-NPs) have wide applications in several sectors due to their high resistance to corrosion as well as oxidation, ecofriendly nature, cost effectiveness and nontoxic potential. Plant based particles are credible alternatives as they reduce the burden of complicated and laborious protocols of physiochemical reliance. In this study, GCoO-NPs were synthesized using the grape Jumbo Muscadine (Vitis rotundifolia) using co-precipitation. The synthesized GCoO-NPs were characterized by UV–Vis spectrophotometer, Fourier transform infrared spectroscopy (FTIR), Powder X-ray diffraction (PXRD) and Scanning electron microscopy (SEM). The photocatalytic activity of the GCoO-NPs was estimated by the degradation of Acid Blue-74 (AB-74) dye and the complete degradation of 98% was accomplished at the reaction time of 150 min at pH 10 and 60 mg/100 mL concentration. The outcomes of this study indicated the excellent performance of the GCoO-NPs on par with some of the earlier findings and this can be an appealing aspirant of extreme potential to be employed as a catalyst alternative to the conventional wastewater treatment methods.

Publication

Parmosidone K, A New Meta depsidone from The Lichen Parmotrema Tsavoense

( 2020)

Thi-Hoai-Thu Nguyen

;

Thi-My-Nhung Nguyen

;

Thanh-Trung Nguyen

;

Huu-Hung Nguyen

;

Ngoc-Hong Nguyen

;

Dinh-Tri Mai

;

Bui-Linh-Chi Huynh

;

Cong-Luan Tran

;

Thuc-Huy Duong

Further phytochemical investigation on P. tsavoense led to one new meta-depsidone, parmosidone K together with one known compound, barbatic acid. Their structures were determined by 1D and 2D NMR analysis, high resolution mass spectroscopy, and comparison their NMR data with those reported in literatures. Parmosidone K was evaluated for α-glucosidase inhibition and revealed the powerful activity with IC50 value of 3.12 µM.

Publication

Antioxidant activity of some natural essential oils in Vietnam: Comparison between QSAR simulation and experimental study

( 2020)

Tran Thi Ai My

;

Le Trung Hieu

;

Nguyen Thi Thanh Hai

;

Ton Nu My Phuong

;

Huynh Thi Phuong Loan

;

Bui Thi Phuong Thuy

;

Nguyen Thi Ai Nhung

Antioxidant activities of essential oils from leaves of Piper betle L. (T) and Cleistocalyx operculatus L. (V), and aerial parts of Ageratum conyzoides L. (H) natively grown in Thua Thien Hue province of Vietnam were investigated. Quantitative structure–activity relationship (QSAR) model was constructed from the 27 compounds including 4-hydroxy-chromene-2H-one and its derivatives. DPPH (1,1-diphenyl-2-picrylhydrazyl) radical scavenging activity was applied to estimate the antioxidant property of these essential oils through IC50 (μg/mL) values. QSAR model is used to predict the radical scavenging activity IC50 μg/mL of T, V, and H. The results indicate that there is a good agreement between the experimental data and the predicted values using the QSAR model. The three essential oils display the DPPH radical scavenging activities with the IC50 values being in the order of T > H > V of 3.71 μg/mL, 596.44 μg/mL and 637.03 μg/mL, respectively. The essential oil of T exhibits the strong DPPH radical scavenging activity that is close to the reference compound ascorbic acid (IC50 value of 3.03 μg /mL).

Publication

Synthesis of Diphenyl Sulfide from Iodobenzene and Thiophenol using Metal Organic Framework Cu2(NDC)2(DABCO) as An Efficient Heterogeneous Catalyst

( 2020)

Nguyen Van Chi

A metal-organic framework Cu2(NDC)2(DABCO) was synthesized from copper nitrate trihydrate, 2,6-Napthalenedicarboxylic acid (H2NDC), and 1,4-diazabicyclo[2.2.2]octane (DABCO) by solvothermal method. Its physicochemical properties were confirmed by several techniques such as X-ray powder diffraction (PXRD), Fourier transform infrared (FT-IR), scanning electron microscopy (SEM), and transmission electron microscopy (TEM). Cu2(NDC)2(DABCO) appeared as well-shaped crystals. To get diphenyl sulfide as desired product from the C-S cross coupling reaction of iodobenzene and thiophenol, the Cu2(NDC)2(DABCO) was used as heterogeneous catalyst in the presence of LiO-tBu as base. The results showed that the transformation could proceed with more than 93% reaction conversion being obtained after 6 h at 120 oC when using 5 mol% Cu2(NDC)2(DABCO) catalyst in the presence of LiO-tBu. The solid catalyst could be recovered and reused five times without a significant degradation in catalytic activity. The coupling reaction could only proceed to achieve major product in the presence of the Cu2(NDC)2(DABCO catalyst.

Publication

Study on SARS CoV 2 inhibition of some potential drugs using molecular docking simulation

( 2020)

Bùi Thị Phương Thúy

;

Bùi Thị Bảo Trâm

;

Nguyễn Huyền Ngọc Trân

Inhibitory capabilities of six old drugs selected from the DrugBank database including Losartan, Triazavirin, TMC-310911, Verapamil, Clevudine and Elbasvir, which are promising for the treatment of an infectious disease caused by SARS-CoV-2, were examined on the host receptor Angiotensin-converting enzyme 2 (ACE2) and the main protease (PDB6LU7) of SARS-CoV-2 using molecular docking simulation. Results reveal that both proteins ACE2 and PDB6LU7 are in strong inhibition by the drugs and the inhibitory effectiveness is in the order: Clevudine > Triazavirin > TMC-310911 > Elbasvir > Losartan > Verapamil. In particular, the inhibitability highly correlates with the average docking score energy of inhibitory complexes, and drug-protein active interactions. Regarding inhibitory ligands, their polarizability, molecular size, and dispersion coefficient logP are also significant indicators for inhibition potential. The drugs are suggested as valuable resources for selecting potential pharmaceuticals to prevent SARS-CoV-2 invasion into human body given theoretical demonstration of molecular docking simulation.

Publication

A molecular docking simulation study on potent inhibitors against Rhizoctonia solani and Magnaporthe oryzae in rice: silver-tetrylene and bis-silver-tetrylene complexes vs. validamycin and tricyclazole pesticides

( 2020)

Bui Thi Phuong Thuy

;

Tran Thi Ai My

;

Nguyen Thi Thanh Hai

;

Huynh Thi Phuong Loan

;

Le Trung Hieu

;

Tran Thai Hoa

;

Thanh Q. Bui

;

Ho Nhat Tuong

;

Nguyen Thi Thu Thuy

;

Doan Kim Dung

;

Pham Van Tat

;

Phan Tu Quy

;

Nguyen Thi Ai Nhung

Rice, well known as the most important staple food source worldwide, is highly susceptible to many infectious diseases, especially rice sheath blight caused by fungus Rhizoctonia solani and rice blast caused by fungus Magnaporthe oryzae. The inhibitory ability of silver- and bis-silver-tetrylene complexes, including Ag-E and bis-Ag-E with E = C, Si, Ge, onto protein 4G9M in Rhizoctonia solani and protein 6JBR in Magnaporthe oryzae was theoretically investigated using molecular docking simulation methodology. Two commercial pesticides selected as inhibitory references are validamycin for 4G9M and tricyclazole for 6JBR. The results reveal that bis-silver-tetrylene complexes perform the strongest inhibitory effects towards both proteins. The structures of the complexes exhibit good site–site binding to both proteins given the observations on the hydrogen bond interactions, cation–π bonds, π–π bonds, and ionic interactions, interaction distance between amino acids and ligands, and van der Waals interactions. The inhibitory capacity onto protein 4G9M decreases in the following order: bis-Ag-C > bis-Ag-Si > bis-Ag-Ge > validamycin > Ag-C ≈ Ag-Si ≈ Ag-Ge. The corresponding order observed from the study for protein 6JBR is bis- Ag-C > bis-Ag-Si ≈ bis-Ag-Ge > tricyclazole ≈ Ag-C ≈ Ag-Si ≈ Ag-Ge. The study opens a promising approach to tackle rice blast and rice sheath blight based on a family of silver-tetrylene organometallic chemicals given the theoretical proof of environment-advanced properties and molecule-scaled effectiveness.

Publication

Coordination complexes of slight tetrylene with platinum(II)-8-hydroxyquinolines: Structure and bonding analysis

( 2020)

Huynh Thi Phuong Loan

;

Hoang Van Duc

;

Phan Tu Quy

;

Bui Thi Phuong Thuy

;

Pham Van Tat

;

Duong Tuan Quang

;

Nguyen Thi Ai Nhung

The structure and bonding situation in platinum complexes containing slight tetrylene ligands [{PtCl-C9H6NO}-NHE] (Pt-NHE) with E = C, Si, Ge were examined by DFT calculations with the levels are BP86/def2-SVP and BP86/def2-TZVPP. The predicted equilibrium structure of the ligands NHE in Pt-NHE are bonded in distorted end-on way to PtCl-8-hydroxyquinolines fragment with the bending angle, , exhibits the biggest value in carbenes systems then slightly decrease from Pt-NHC to Pt-NHGe. Bond dissociation energies (BDEs), De (kcal.mol-1), decrease from the carbene complex to the weaker bonded silylene and germylene manners. The BDE when considering dispersion correction at the BP86-D3(BJ)/def2-TZVPP level confirms that Pt-E bond in Pt-NHE belongs to the effect of the bulky group in slight tetrylene NHE and Pt(II)-group fragment which makes the intrinsic Pt-E bond strength decreases from carbene to germylene complexes. The hybridization of atoms E and Pt have large p characters while the hybridization of atom Pt has greater d character which lead to the Pt-E bond possesses not only NHE→{PtCl-C9H6NO} strong -donation but also a significant contribution π-donation NHE→{PtCl-C9H6NO} and weak π-backdonation metal-ligand NHE←{PtCl-C9H6NO} in complexes Pt-NHE.

Publication

Phân lập và định danh vi khuẩn xử lý Ammonium từ bùn thải chăn nuôi heo, bùn ao cá tra và bùn ao nuôi tôm

( 2020)

Châu Tấn Phát

Nghiên cứu tập trung sàng lọc vi khuẩn xử lí ammonium từ các mẫu bùn thải trong chăn nuôi. Mẫu được thu tại các khu vực thuộc TP. Hồ Chí Minh, Tiền Giang và Bến Tre. Nhóm vi khuẩn có khả năng xử lý ammonium phân lập từ nguồn bùn thải chăn nuôi heo, bùn ao cá tra, bùn ao tôm dao động lần lượt trong khoảng (1,5 2,4) x 10 MPN/g; (0,15 - 1,5) x 10 MPN/g và (0,93 – 2,4) x 10 MPN/g. Dựa vào đặc điểm hình thái và sinh hóa, đã tuyển chọn được 6 chủng vi khuẩn có đặc điểm giống ParacoCcus và 3 chủng giống Nitrosomonas. Bốn chủng có hoạt tính xử lý ammonium cao nhất (120,83- 123,66 mg/L) sau khi nuôi cấy trong 168 h được chọn để thực hiện giải trình tự 16S rRNA Kết quả giải trình tự và so sánh với dữ liệu trên ngân hàng gen (GenBank) cho thấy: 02 chủng S4 và S6 tương đồng với Paracoccus communis (99%). chủng S9 tương đồng với Paracoccus versutus (100%), chủng S3 tương đồng với Nitrosomonas europaea (100%). Hai chủng S4 và S6 thuộc loài Paracoccus communis đã cho thấy khả năng xử h ammonium lên đến 74,9% và 76,65%. Đây là lần đầu tiên Paracoccus communis được phân lập từ bùn thải và được báo cáo là vi khuẩn có khả năng xử lí amonium

Publication

A new resorcinol derivative from the bark of Aegiceras floridum (Primulaceae)

( 2020)

Huynh-Van-Long Luu

;

Thi-Hoai-Thu Nguyen

;

Kim-Phi-Phung Nguyen

;

Huu-Hung Nguyen

;

Ngoc-Hong Nguyen

;

Thuc-Huy Duong

Chemical investigation of the Vietnamese plant Aegiceras floridum Roem. & Schult. (Primulaceae) led to the isolation of the new compound 3-methoxy-5-nonylphenol (1) along with five known ones 2,8,10-trihydroxy-6H-benzo[c]chromen-6-one (2), 2-hydroxy-5-methoxy-3-nonylbenzo-1,4-quinone (3), 5-(3-hydroxypropyl)-7-methoxy-3-(methylbenzofuran-2-yl)-3-methoxyphenol (4), 2,8-dihydroxy-7-methoxy-3,9-diundecyldibenzofuran-1,4-dione (5) and 10-hydroxy-4-methoxy-2,11-diundecylgomphilactone (6). The structures were elucidated by analysis of their HRESIMS and NMR data as well as the comparison of their NMR data with those reported in the literature. The cytotoxic activity of selected isolated compounds against some cancer cell lines such as human epithelial carcinoma (HeLa), human lung cancer (NCI-H460), liver hepatocellular carcinoma (HepG2), human breast cancer (MCF-7), and acute T cell leukemia (Jurkat) was evaluated. Among them, 3 showed moderate activities against MCF-7 with an IC50 of 17.77 µM and NCI-H460 with an IC50 of 25.02 µM. The result of DPPH radical scavenging activity assay indicated that compounds 2–4 and 6 revealed weak antioxidant activity.

Publication

A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation

( 2020)

Thanh Q. Bui

;

Huynh Thi Phuong Loan

;

Tran Thi Ai My

;

Duong Tuan Quang

;

Bui Thi Phuong Thuy

;

Vo Duy Nhan

;

Phan Tu Quy

;

Pham Van Tat

;

Duy Quang Dao

;

Nguyen Tien Trung

;

Lam K. Huynh

;

Nguyen Thi Ai Nhung

Ribavirin and remdesivir have been preclinically reported as potential drugs for the treatment of SARS-CoV- 2 infection, while light silver tetrylene complexes (NHEPh–AgCl and (NHEPh–AgCl)2 with E ¼ C, Si, and Ge) have gained significant interest due to their promising applicability on the cytological scale. Firstly, the structures and bonding states of silver–tetrylene complexes (NHE–Ag) and bis-silver–tetrylene complexes (NHE–Ag-bis) were investigated using density functional theory (DFT) at the BP86 level with the def2-SVP and def2-TZVPP basis sets. Secondly, the inhibitory capabilities of the carbene complexes (NHC–Ag and NHC–Ag-bis) and the two potential drugs (ribavirin and remdesivir) on human-protein ACE2 and SARS-CoV-2 protease PDB6LU7 were evaluated using molecular docking simulation. The carbene ligand NHC bonds in a head-on configuration with AgCl and (AgCl)2, whereas, the other NHE (E ¼ Si and Ge) tetrylene ligands bond in a side-on mode to the metal fragments. The bond dissociation energy (BDE) of the NHE–Ag bond in the complex families follows the order of NHC–Ag > NHSi–Ag > NHGe–Ag and NHSi–Ag-bis > NHGe–Ag-bis > NHC–Ag-bis. The natural bond orbital analysis implies that the [NHEPh/AgCl] and [(NHEPh)2/(AgCl)2] donations are derived mainly from the s- and pcontributions of the ligands. The docking results indicate that both the ACE2 and PDB6LU7 proteins are strongly inhibited by silver–carbene NHC–Ag, bis-silver–carbene NHC–Ag-bis, ribavirin, and remdesivir with the docking score energy values varying from 17.5 to 16.5 kcal mol 1 and 16.9 to 16.6 kcal mol 1, respectively. The root-mean-square deviation values were recorded to be less than 2 A in all the calculated systems. Thus, the present study suggests that silver–carbene NHC–Ag and bissilver– carbene NHC–Ag-bis complexes are potential candidates to inhibit ACE2 and PDB6LU7, and thus potentially conducive to prevent infection caused by the SARS-CoV-2 virus.

Publication

Allelopathic Potential of Rice and Identification of Published Allelochemicals by Cloud Based Metabolomics Platform

( 2020)

Vũ Công Danh

The methanol extracts of nine popular cultivated Vietnamese rice cultivars (Oryza sativa L.cv. OM 2395, 5451, 6976, 380, 5930, 4498, 3536, N406, and 7347) were used to explore their allelopathic potential on barnyardgrass (Echinochola crus-galli L.). At 0.1 g mL􀀀1, OM 5930, OM 4498, and OM 6976 correlatively possessed greatest phytotoxicity on barnyardgrass shoot (98.77%, 90.75%, and 87.17%) and root (99.39%, 92.83%, and 86.56%) growth. The following study aimed to detect previously-known allelochemicals in those rice using XCMS online cloud-based metabolomics platform. Twenty allelochemicals were semi-quantified and seven of them were detected predominantly and five was putatively confirmed in OM 5930 (mg/ 100g fresh rice) as salicylic acid (5.0076), vanillic acid (0.1246), p-coumaric acid (0.1590), 2,4-dimethoxybenzoic acid (0.1045), and cinnamic acid (3.3230). These compounds were active at concentrations greater than 0.5mMand the average EC50 were 1.24 mM. The results indicated thatOM5930 may use as promising candidates in weed biological control for rice production.

Publication

Investigation into SARS-CoV-2 Resistance of Compounds in Garlic Essential Oil

( 2020)

Bui Thi Phuong Thuy

;

Tran Thi Ai My

;

Nguyen Thi Thanh Hai

;

Le Trung Hieu

;

Tran Thai Hoa

;

Huynh Thi Phuong Loan

;

Nguyen Thanh Triet

;

Tran Thi Van Anh

;

Phan Tu Quy

;

Pham Van Tat

;

Nguyen Van Hue

;

Duong Tuan Quang

;

Nguyen Tien Trung

;

Vo Thanh Tung

;

Lam K. Huynh

;

Nguyen Thi Ai Nhung

Eighteen active substances, including 17 organosulfur compounds found in garlic essential oil (T), were identified by GC−MS analysis. For the first time, using the molecular docking technique, we report the inhibitory effect of the considered compounds on the host receptor angiotensin-converting enzyme 2 (ACE2) protein in the human body that leads to a crucial foundation about coronavirus resistance of individual compounds on the main protease (PDB6LU7) protein of SARS-CoV-2. The results show that the 17 organosulfur compounds, accounting for 99.4% contents of the garlic essential oil, have strong interactions with the amino acids of the ACE2 protein and the main protease PDB6LU7 of SARS-CoV- 2. The strongest anticoronavirus activity is expressed in allyl disulfide and allyl trisulfide, which account for the highest content in the garlic essential oil (51.3%). Interestingly, docking results indicate the synergistic interactions of the 17 substances, which exhibit good inhibition of the ACE2 and PDB6LU7 proteins. The results suggest that the garlic essential oil is a valuable natural antivirus source, which contributes to preventing the invasion of coronavirus into the human body

Publication

A Review on: Extraction and Analysis of Phenolics in plants A Case Study in Basil Leaves

( 2020)

Ma Bich Nhu

;

Phan Phuoc Hien

Phenolic compounds are abundant in majority of food researches because of having numerous positive effects for health-protecting properties and enhancement. Similarly, it has been reported to possess antioxidant properties in basil leaves (Ocimum basilicum L.). Moreover, its phenolic compounds include simple phenol, hydrobenzonic acid and cinnamic acid derivatives, flavonoids, tannins, among others. The extraction of phenolics from raw materials is the first step for their analysis. Therefore, this paper provides a summary of background information and the extraction methods used for the analysis of phenolics in this plant material, especially in basil leaves, a case study.

Publication

Metal organic Framework 118 (MOF 118): A Heterogeneous Catalyst for Effective Synthesis of Pyrroles from Aryl Amines and 2,5 hexanedione

( 2020)

Nguyen Van Chi

;

Nguyen Thi Hong Huong

Metal-organic frameworks (MOFs) have been widely used in many applications, particularly catalysis. Here, we reported the synthesis and characteristics of metal–organic framework-118 (MOF-118), which was used for pyrroles synthesis via Paal-Knorr reaction between diketone and aryl amines. It was found that MOF-118 exhibited excellent activity in the reaction between p-anisidine and 2,5-hexanedione. The reaction parameters including catalyst concentrations, reaction temperatures, molar ratio of p-anisidine/2,5-hexadione, and solvents, were systematically investigated. Almost 100% conversion was achieved under the optimized reaction conditions. The reusability of MOF-118 catalyst was studied. Furthermore, we demonstrated that the functional groups on aryl amines have strongly effect on the reaction rate.

Publication

Design and synthesis of new lupeol derivatives and their α-glucosidase inhibitory and cytotoxic activities

( 2020)

Hoang-Vinh-Truong Phan

;

Thuc-Huy Duong

;

Duc-Dung Pham

;

Hoang-Anh Pham

;

Van-Kieu Nguyen

;

Thi-Phuong Nguyen

;

Huu-Hung Nguyen

;

Ngoc-Hong Nguyen

;

Pornpat Sam-ang

;

Kiettipum Phontree

;

Jirapast Sichaem

were designed, synthesised and evaluated for their a-glucosidase inhibitory and cytotoxic activities. Among synthetic derivatives, lupeol analogues 2b and 2e containing a benzylidene chain exhibited the best activity against a-glucosidase and superior to the positive agent with the IC50 values of 29.4 ± 1.33 and 20.1 ± 0.91 lM, respectively. Lupeol analogues 2d and 3a showed weak cytotoxicity against K562 cell line with the IC50 values of 76.6 ± 2.40 and 94.4 ± 1.51 lM, respectively.

Publication

Prediction of the Spin-Parities and the Magnetic Moments for the Ground States of Proton-rich Nuclei with Z = 21–30

( 2020)

Nguyen Duy Ly

;

Latsamy Xayavong

;

Nguyen Kim Uyen

;

Vinh N. T. Pham

;

T. V. Nhan Hao

;

Nguyen Ngoc Duy

The present paper reports on the spin-parities and the magnetic moments for the ground states of 44 proton-rich isotopes with Z = 21−30 and A = 36−57, which are important for studies of either reaction rates in X-ray bursts or nuclear structure. These nuclear properties were calculated based on the single-particle shell model. The spins of the concerned nuclei were compared to available experimental data adopted from the NuDat database to evaluate the variations in the astrophysical rates of the rp-process reactions. We found discrepancies, due to the deformed nuclear structure, between the present results and those reported in the NuDat database. The spin uncertainties result in large variations, 13% – 200%, in the astrophysical rates of the rp-process reactions. In particular, the spin uncertainties of the 44V and the 46−49Mn isotopes significantly affect the astrophysical rates of the reverse reactions of the proton captures 43Ti(p, γ)44V(p, γ)45Cr, 45Cr(p, γ)46Mn(p, γ)47Fe, 47Mn(p, γ)48Fe, 47Cr(p, γ)48Mn(p, γ)49Fe, and 48Cr(p, γ)49Mn(p, γ)50Fe. Moreover, the magnetic moments of most of the isotopes were predicted for the first time. The results show that the magnetic moments are in the order of μp(1f7/2) > μp(2p3/2) > μn(1d3/2) > μn(1f7/2) for the nuclei having an unpaired nucleon in the proton/neutron shells. The present study suggests that reliable calculations and/or measurements for the properties of proton-rich nuclei are highly demanded.

Publication

Evaluation of the Anti Inflammatory and Anticancer Activities of Catechins Extracted from Green Tea (Camellia Sinensis) in Some Cancer Cell Lines

( 2020)

Ho Thi Ngoc Tram

Catechins from Green tea (Camellia sinensis) is widely known for many biological activities, special anti-cancer and anti-inflammatory properties. Catechins were extracted by mechanical blending, and using citric acid, with 2.31% in extraction efficiency. The result of determining by HPLC-UV showed that Catechin< EC < EGC < ECG < EGCG in concentration compared to dry powder, reaching a total content of 634.51 mg/g, higher than tea powder (537.65 mg/g). Then, anti-inflammatory and anticancer activities of these extracts were investigated. Cell viability assay (MTT) showed that catechin extracts were not toxic to Normal Human Dermal Fibroblasts Cells. They even exhibited anti-inflammatory activities by suppressing the production of NO and proinflammatory cytokines. The results also showed that the extracted catechin powder also showed good anti-inflammatory activity, at a concentration of 45 ?g/mL, NO proliferation reached 44.4%. Anticancer activities of these extracts were displayed through their ability to inhibit the growth of cancer cell lines: liver cancer cell line (HepG2), lung cancer cell line (A549), leukemia cancer cell line (K562), with IC50 values of 181.1 μg/mL, 186 μg/mL, 137.8 μg/mL, respectively. So catechin extracts from green tea may have the potential to be applied in pharmaceutical.

Publication

An overview of phytochemicals and potential health-promoting properties of black walnut

( 2020)

Danh C. Vu

;

Trang H. D. Nguyen

;

Thi L. Ho

Black walnut (Juglans nigra L.) is one of the most widely consumed nuts in the United States. The nut has been recognized for its unique, bold flavor, and used as a versatile food ingredient. The objective of this review is to summarize available research data pertaining to phytochemicals present in black walnut and their previously reported health-promoting properties. Black walnut is rich in phenolics and contains higher levels of phytosterols, unsaturated fatty acids and tocopherols than many other commonly consumed nuts. Dietary intervention of these constituents has been associated with a great number of disease-preventive properties. Black walnut has a potential to inhibit the release of proinflammatory mediators in vitro. Similarities in contents of unsaturated fatty acids and tocopherols between black walnut and English walnut suggest that black walnut consumption may produce beneficial effects on cardiovascular disease risks. In addition, the high level of g-tocopherol in black walnut could make the nut a cancer-preventive option. Although evidence has shown black walnut kernel is a rich source of phytochemicals of potential importance to human health, there is a paucity of in vitro and in vivo studies on the bioactivities of these phytochemicals isolated from black walnut and the health-promoting properties of black walnut consumption. Clinical studies are needed to better understand the health benefits of black walnut.

Publication

Design, modification of phyllanthone derivatives as anti-diabetic and cytotoxic agents

( 2020)

Ngoc-Hong Nguyen

;

Van-Giau Vo

;

Hoang-Vinh-Truong Phan

;

Thanh-The Ngo

;

Jirapast Sichaem

;

Thi-Phuong Nguyen

;

Huu-Hung Nguyen

;

Duc-Dung Pham

;

Tien-Cong Nguyen

;

Van-Kieu Nguyen

;

Thuc-Huy Duong

Twelve benzylidene derivatives, one Baeyer-Villiger oxidative, six imine derivatives were successfully designed and synthesized from phyllanthone. In the search for potential new anti-diabetic agents, phyllanthone along with its benzylidene and oxidation analogues were evaluated for enzyme inhibition against α-glucosidase. In the benzylidene series, most analogues displayed stronger activity than the mother compound. 1c revealed the strongest activity, outperforming the acarbose positive control with an IC50 value of 19.59 μM. Phyllanthone and its derivatives were then tested for cytotoxic activity against the K562 cell line. The imine analogues displayed the most powerful cytotoxic activity with 3c, 3d having IC50 values of 57.55 and 68.02 μM, respectively.

Publication

Two new phenolic compounds from the Vietnamese lichen Parmotrema tinctorum

( 2020)

Van-Muoi Bui

;

Thuc-Huy Duong

;

Thi-Anh-Minh Nguyen

;

Thi-Ngoc-Van Nguyen

;

Ngoc-Hong Nguyen

;

Huu-Hung Nguyen

;

Warinthorn Chavasiri

;

Kim-Phi-Phung Nguyen

;

Bui-Linh-Chi Huynh

Chemical investigation of the lichen Parmotrema tinctorum (Nyl.) Hale led to the isolation of two new phenolic compounds, 2-ethylhexyl orsellinate (1) and tinctorinone (2). The structures were determined by analysis of their MS and NMR data as well as by comparison with literature data. The 2-ethylhexyl ester group of 2-ethylhexyl orsellinate is uncommon among lichen metabolites. Tinctorinone revealed strong inhibition towards α-glucosidase.

Journal Articles - Natural Science - 2020

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